ナイキ ヨシカズ   NAIKI Yoshikazu
  内記 良一
   所属   歯学部 微生物学
   職種   講師
言語種別 英語
発行・発表の年月 2018/12/01
形態種別 学術雑誌
査読 査読あり
標題 NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.
執筆形態 共著
掲載誌名 Molecular Medicine Reports
掲載区分国外
巻・号・頁 18(6),pp.5279-5285
著者・共著者 Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
概要 We investigated whether the NF-κB inhibitor DHMEQ inhibits IL-1β production by titanium dioxide nanoparticles in THP-1 macrophages. IL-1β maturation is required in the NLRP3 inflammasome, but DHMEQ reduced NLRP3 mRNA expression and caspase-1 activity. Inhibition of pro-IL-1β expression by DHMEQ inhibits mature IL-1β production. Therefore, it was suggested that DHMEQ may help improve the inflammation of the trachea and lungs caused by the inhalation of PM2.5.