ナイキ ヨシカズ
NAIKI Yoshikazu
内記 良一 所属 歯学部 微生物学 職種 講師 |
|
言語種別 | 英語 |
発行・発表の年月 | 2018/12/01 |
形態種別 | 学術雑誌 |
査読 | 査読あり |
標題 | NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model. |
執筆形態 | 共著 |
掲載誌名 | Molecular Medicine Reports |
掲載区分 | 国外 |
巻・号・頁 | 18(6),pp.5279-5285 |
著者・共著者 | Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K. |
概要 | We investigated whether the NF-κB inhibitor DHMEQ inhibits IL-1β production by titanium dioxide nanoparticles in THP-1 macrophages. IL-1β maturation is required in the NLRP3 inflammasome, but DHMEQ reduced NLRP3 mRNA expression and caspase-1 activity. Inhibition of pro-IL-1β expression by DHMEQ inhibits mature IL-1β production. Therefore, it was suggested that DHMEQ may help improve the inflammation of the trachea and lungs caused by the inhalation of PM2.5. |